Section of Adult Congenital and Adult Heart Disease, Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Via W. A. Mozart 9, 37040 Legnago, Verona, Italy.
Nat Rev Cardiol. 2010 Jul;7(7):361-2. doi: 10.1038/nrcardio.2010.73.
The relationship between patent foramen ovale and migraine is a hotly debated issue. Conflicting data on the association or independence of these conditions have been reported by various study groups around the world. Now, a large-scale case-control study has shown no association between the two entities; however, there were a number of methodological flaws in this study and we are unlikely to see the end of the controversy in the near future.
卵圆孔未闭与偏头痛之间的关系是一个备受争议的问题。世界各地的不同研究小组报告了关于这些病症之间存在关联或独立的相互矛盾的数据。现在，一项大规模的病例对照研究表明这两者之间没有关联；然而，这项研究存在许多方法学上的缺陷，我们不太可能在近期看到争议的结束。
