Wu Xiao-jun, Fang Yu-jin, Lu Zhen-hai, Lin Jun-zhong, Wan De-sen, Ding Pei-rong, Chen Gong, Li Li-ren, Kong Ling-heng, Pan Zhi-zhong
Department of Colorectal Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Jun;13(6):417-20.
To analyze the outcome of the patients with gastric gastrointestinal stromal tumor(GIST) after surgical treatment and identify the associated risk factors.
Clinical data and the tissue slices including immunohistochemistry staining of 140 patients with gastric GIST from January 1990 to December 2008 were retrospectively reviewed. SPSS 16.0 for Windows software package was used for statistical analysis.
The overall survival rates of 1-, 3-, 5-year were 96.8%, 86.7% and 79.3%, respectively. The survival rates of 1-, 3-, 5-year were 98.1%, 90.0% and 85.4% in patients who underwent complete tumor resection. But the survival rates of 1-, 3-, 5-year were 38.1%, 0 and 0 in patients with incomplete tumor resection. The differences were statistically significant (P<0.05). Gender, preoperative metastasis, tumor size,pathology type,karyokinesis, recurrence and metastasis were associated with survival rates in patients with complete tumor resection by univariate analysis. However, only tumor size, karyokinesis, recurrence and metastasis were associated with survival rates by Cox regression multivariable analysis(P<0.05).
Surgery remains the main treatment for gastric GIST. Local complete resection is the principal treatment.
分析胃胃肠道间质瘤（GIST）患者手术治疗后的结局，并确定相关危险因素。
回顾性分析1990年1月至2008年12月期间140例胃GIST患者的临床资料及组织切片，包括免疫组化染色。采用SPSS 16.0 Windows软件包进行统计分析。
1年、3年、5年总生存率分别为96.8%、86.7%和79.3%。肿瘤完全切除患者的1年、3年、5年生存率分别为98.1%、90.0%和85.4%。而肿瘤切除不完全患者的1年、3年、5年生存率分别为38.1%、0和0。差异有统计学意义（P<0.05）。单因素分析显示，性别、术前转移、肿瘤大小、病理类型、核分裂象、复发和转移与肿瘤完全切除患者的生存率相关。然而，多因素Cox回归分析显示，仅肿瘤大小、核分裂象、复发和转移与生存率相关（P<0.05）。
手术仍然是胃GIST的主要治疗方法。局部完整切除是主要治疗手段。
