Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
Biopolymers. 2010 Sep;93(9):755-63. doi: 10.1002/bip.21428.
The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi-billion dollar drug, simvastatin (Zocor). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels-Alderase enzyme activity is utilized in its biosynthesis. This review examines the biosynthesis of lovastatin, as well as of compactin, equisetin, cytochalasins, and solanapyrones, which are other structurally related polyketides that appear to utilize a Diels-Alderase.
真菌聚酮类洛伐他汀是一种降低胆固醇的药物，是一种价值数十亿美元的药物辛伐他汀（Zocor）的直接前体。洛伐他汀由一种称为 LovB 的迭代型 I 聚酮合酶和一种伴侣烯酰还原酶（LovC）产生。有证据表明，Diels-Alderase 酶活性在其生物合成中被利用。这篇综述考察了洛伐他汀的生物合成，以及其他结构相关的聚酮类化合物的生物合成，如康普他汀、equisetin、细胞松弛素和 solanapyrones，它们似乎利用了 Diels-Alderase。
