脑白质疏松症的血管体内标志性特征。
In vivo vascular hallmarks of diffuse leukoaraiosis.
机构信息
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
出版信息
J Magn Reson Imaging. 2010 Jul;32(1):184-90. doi: 10.1002/jmri.22209.
PURPOSE
To characterize multiple patterns of vascular changes in leukoaraiosis using in vivo magnetic resonance imaging (MRI) techniques.
MATERIALS AND METHODS
We measured cerebral blood flow (CBF), cerebrovascular reactivity (CVR), and blood-brain-barrier (BBB) leakage in a group of 33 elderly subjects (age: 72.3 +/- 6.8 years, 17 males, 16 females). Leukoaraiosis brain regions were identified in each subject using fluid-attenuated inversion-recovery (FLAIR) MRI. Vascular parameters in the leukoaraiosis regions were compared to those in the normal-appearing white matter (NAWM) regions. Vascular changes in leukoaraiosis were also compared to structural damage as assessed by diffusion tensor imaging.
RESULTS
CBF and CVR in leukoaraiosis regions were found to be 39.7 +/- 5.2% (P < 0.001) and 52.5 +/- 11.6% (P = 0.005), respectively, of those in NAWM. In subjects who did not have significant leukoaraiosis, CBF and CVR in regions with high risk for leukoaraiosis showed a slight reduction compared to the other white matter regions. Significant BBB leakage was also detected (P = 0.003) in leukoaraiosis and the extent of BBB leakage was positively correlated with mean diffusivity. In addition, CVR in NAWM was lower than that in white matter of subjects without significant leukoaraiosis.
CONCLUSION
Leukoaraiosis was characterized by reduced CBF, CVR, and a leakage in the BBB.
目的
利用活体磁共振成像（MRI）技术对脑白质疏松症的多种血管变化模式进行特征描述。
材料和方法
我们测量了一组 33 名老年受试者（年龄：72.3±6.8 岁，17 名男性，16 名女性）的脑血流（CBF）、脑血管反应性（CVR）和血脑屏障（BBB）渗漏。使用液体衰减反转恢复（FLAIR）MRI 在每位受试者中识别脑白质疏松症脑区。将脑白质疏松症区域的血管参数与正常外观的白质（NAWM）区域进行比较。还将脑白质疏松症的血管变化与扩散张量成像评估的结构损伤进行比较。
结果
发现脑白质疏松症区域的 CBF 和 CVR 分别为 5.2±11.6%（P=0.005）和 39.7±5.2%（P<0.001），分别为 NAWM 的 52.5±11.6%和 39.7±5.2%。在没有明显脑白质疏松症的受试者中，具有脑白质疏松症高风险的区域的 CBF 和 CVR 与其他白质区域相比略有降低。还检测到明显的 BBB 渗漏（P=0.003）在脑白质疏松症中，BBB 渗漏的程度与平均弥散度呈正相关。此外，NAWM 的 CVR 低于无明显脑白质疏松症受试者的白质。
结论
脑白质疏松症的特征是 CBF、CVR 和 BBB 渗漏减少。
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