Khodzhakuliev B G, Naumov V G, Leleko V V, Belenkov Iu N
Ter Arkh. 1991;63(1):52-5.
Anti-arrhytmic activity of cordarone was studied in 68 patients with circulatory failure (CF) and heart rhythm disorders with the aid of the 48-hour monitoring of the ECG. Cordarone was administered after the maintenance therapy with digoxin (the mean concentration of digoxin in the plasma 1.38 +/- 0.09 ng/ml) at an average dose of 300 mg/day. Cordarone suppressed supraventricular premature heart beat by 80.2%, ventricular premature heart beat (VPHB) by 76.4%, group VPHB by 82.9% and runnings of ventricular tachycardia by 86.6%. Antiarrhythmic activity of cordarone was more remarkable at the early stages of CF. The concentration of digoxin in the plasma did not exceed the mean therapeutic one. Therefore, cordarone possesses a high antiarrhythmic activity, with its efficacy being significantly higher in patients with moderately pronounced CF. At the same time cordarone influences to a less measure the quality of ventricular rhythm disorders in patients with severe CF and apparently does not avert the cases of sudden death in such patients.
借助心电图48小时监测，对68例循环衰竭（CF）和心律紊乱患者研究了可达龙的抗心律失常活性。在使用地高辛维持治疗后（地高辛血浆平均浓度为1.38±0.09 ng/ml）给予可达龙，平均剂量为300mg/天。可达龙使室上性早搏抑制率达80.2%，室性早搏（VPHB）抑制率达76.4%，成串室性早搏抑制率达82.9%，室性心动过速发作抑制率达86.6%。可达龙的抗心律失常活性在CF早期更为显著。血浆地高辛浓度未超过平均治疗浓度。因此，可达龙具有较高的抗心律失常活性，在中度CF患者中其疗效显著更高。同时，可达龙对重度CF患者心室节律紊乱质量的影响较小，显然不能避免此类患者的猝死情况。
