Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305-5719, USA.
Biol Psychiatry. 2010 Sep 1;68(5):491-3. doi: 10.1016/j.biopsych.2010.05.010. Epub 2010 Jun 26.
The purpose of this study was to investigate prefrontal cortex (PFC) volumes in youth with posttraumatic stress symptoms (PTSS) and explore the relationship between cortisol secretion and PFC volumes.
Total brain tissue volumes, segmented areas of the PFC, and diurnal cortisol secretion were examined in a sample of 33 youth aged 10 to 16 years. Cerebral volumes were available for 45 subjects (30 PTSS and 15 control subjects).
Youth with PTSS had significantly decreased total brain tissue and total cerebral gray volumes in comparison with healthy control subjects. While controlling for total cerebral gray volume, the PTSS group demonstrated decreased left ventral and left inferior prefrontal gray volumes. A significant negative association was found between prebedtime cortisol levels and left ventral PFC gray volumes for the full sample.
Findings suggest associations between posttraumatic stress and PFC neurodevelopment. Findings also suggest a link between PFC development and cortisol secretion.
本研究旨在探讨创伤后应激症状(PTSS)青少年的前额叶皮层(PFC)体积,并探讨皮质醇分泌与 PFC 体积之间的关系。
对 33 名 10 至 16 岁的青少年进行了全脑组织体积、PFC 分块区域和日间皮质醇分泌的检查。有 45 名受试者(30 名 PTSS 和 15 名对照)可获得脑体积数据。
与健康对照组相比,PTSS 青少年的总脑组织和总脑灰质体积明显减少。在控制总脑灰质体积的情况下,PTSS 组显示左侧腹侧和左侧下前额叶灰质体积减少。对于全样本,发现睡前皮质醇水平与左侧腹侧 PFC 灰质体积呈显著负相关。
研究结果提示创伤后应激与 PFC 神经发育之间存在关联。研究结果还提示 PFC 发育与皮质醇分泌之间存在联系。