Department of Genetics, The MD Anderson Cancer Center, Houston, TX 77030, USA.
FEBS Lett. 2010 Sep 10;584(17):3773-8. doi: 10.1016/j.febslet.2010.06.016. Epub 2010 Jun 19.
The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the "end zone" of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres.
真核生物染色体的线性性质使得天然 DNA 末端容易引发 DNA 损伤反应。端粒是一种特殊的核蛋白结构，构成染色体的“末端区域”。除了具有特殊的序列和结构外，端粒上还有六种常驻蛋白，它们在保护染色体末端方面发挥着重要作用。在这篇综述中，我们讨论了这个被称为“庇护素”的蛋白质团队，以及它如何参与调节端粒处的 DNA 损伤信号转导、修复和复制。
