Sci Total Environ. 2010 Aug 15;408(18):3719-24. doi: 10.1016/j.scitotenv.2010.05.009. Epub 2010 Jun 26.
This special issue covers the main results of the European Sixth Framework Integrated Research project NoMiracle (Novel Methods for Risk Assessment of Cumulative stressors in Europe). New tools to analyse, characterise and quantify the combined risks to health or the environment from multiple stressors are presented or reviewed. Examples of cumulative stressors are mixtures of chemicals alone or in combination with biological or physical environmental factors such as pathogens and climate extremes. Among the main findings, the scientific work points at the importance of time in dealing with toxicity, and in particular the toxicity of chemical mixtures, the natures of the uncertainties associated with risk assessment and the value of visualisation in identifying and quantifying the most relevant risks. A major conclusion of the project is that researchers and regulators should focus on the receptor rather than on the single stressor or combination of agents. There is also a need for more efforts on mechanistic understanding and for a mechanism-based framework for interpreting mixture/multiple stressor effects. The new tools are available on the internet (http://nomiracle.jrc.ec.europa.eu).
本期特刊涵盖了欧洲第六框架综合研究项目 NoMiracle（欧洲累积压力源风险评估新方法）的主要成果。本文介绍或回顾了用于分析、描述和量化多种压力源对健康或环境的综合风险的新工具。累积压力源的例子包括化学物质的混合物，单独或与生物或物理环境因素（如病原体和气候极端事件）结合。在主要发现中，科学研究指出了在处理毒性方面时间的重要性，特别是化学混合物的毒性、与风险评估相关的不确定性的性质，以及在识别和量化最相关风险方面的可视化价值。该项目的一个主要结论是，研究人员和监管机构应将重点放在受体上，而不是放在单个压力源或组合剂上。还需要在机制理解上付出更多努力，并建立基于机制的框架来解释混合物/多种压力源的影响。新工具可在互联网上获得（http://nomiracle.jrc.ec.europa.eu）。
