Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, 14000 México, DF, Mexico.
J Steroid Biochem Mol Biol. 2010 Oct;122(4):107-13. doi: 10.1016/j.jsbmb.2010.05.003. Epub 2010 May 16.
The endocrine pancreas is central in the physiopathology of diabetes mellitus. Nutrients and hormones control endocrine pancreatic function and the secretion of insulin and other pancreatic islet hormones. Although the pancreas is not usually considered as a target of steroids, increasing evidence indicates that sex steroid hormones modify pancreatic islet function. The biological effects of steroid hormones are transduced by both, classical and non-classical steroid receptors that in turn produce slow genomic and rapid non-genomic responses. In this review, we focused on the effects of sex steroid hormones on endocrine pancreatic function, with special emphasis in animal studies.
内分泌胰腺在糖尿病的病理生理学中起着核心作用。营养物质和激素控制着内分泌胰腺的功能以及胰岛素和其他胰岛激素的分泌。尽管胰腺通常不被认为是类固醇的靶标，但越来越多的证据表明，性激素会改变胰岛功能。类固醇激素的生物学效应通过经典和非经典的类固醇受体传递，进而产生缓慢的基因组和快速的非基因组反应。在这篇综述中，我们重点关注了性激素对内分泌胰腺功能的影响，特别强调了动物研究。
