Morales-Miranda Angélica, Robles-Díaz Guillermo, Díaz-Sánchez Vicente
Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, México, D F.
Rev Invest Clin. 2007 Mar-Apr;59(2):124-9.
The relation between steroid hormones and pancreatic function has been poorly discussed and not very well understood. In general, there is a lack of recognition among the scientific community about the importance of steroids in pancreatic function (current paradigm). In the present article we present basic, as well as clinic and epidemiologic data that demonstrate steroid synthesis and steroid biotransformation by pancreatic tissue, how exocrine and endocrine functions are modulated by steroids, the gender specific frequency and behavior of some tumors and the use of synthetic steroids and steroid action antagonists as therapeutic agents. With the available information it is possible to establish that: 1. Pancreatic tissue synthesize and transform steroid hormones. 2. Pancreatic tissue respond to steroid hormones and express steroid specific receptor molecules. 3. Some endocrine functions such as insulin synthesis and release are modulated by steroids. 4. Tumor growth is modulated by steroids and anti-steroid drugs. This set of data creates a new paradigm for the holistic study of pancreas and opens new research fields. The application of this new paradigm might result in an increase in the knowledge of pancreatic physiology, in the design of new and better diagnostic methods and eventually in the design of more effective medical treatments for the pancreatic cancers.
类固醇激素与胰腺功能之间的关系一直鲜有讨论，人们对此也了解甚少。总体而言，科学界尚未充分认识到类固醇在胰腺功能中的重要性（当前范式）。在本文中，我们展示了基础、临床和流行病学数据，这些数据表明胰腺组织能够合成和进行类固醇生物转化，类固醇如何调节外分泌和内分泌功能，某些肿瘤的性别特异性发生率和行为，以及合成类固醇和类固醇作用拮抗剂作为治疗药物的应用。根据现有信息，可以确定：1. 胰腺组织能够合成和转化类固醇激素。2. 胰腺组织对类固醇激素有反应并表达类固醇特异性受体分子。3. 某些内分泌功能，如胰岛素的合成和释放，受类固醇调节。4. 肿瘤生长受类固醇和抗类固醇药物调节。这组数据为胰腺的整体研究创造了一个新范式，并开辟了新的研究领域。应用这一新范式可能会增加对胰腺生理学的认识，设计出新的、更好的诊断方法，并最终为胰腺癌设计出更有效的治疗方法。
