Department of Biology, University of Copenhagen, Copenhagen N, Denmark.
FEBS Lett. 2010 Sep 10;584(17):3696-702. doi: 10.1016/j.febslet.2010.05.037. Epub 2010 May 24.
Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic degradation or incomplete replication. Here, we review the mechanisms that contribute to regulating mitotic homologous recombination at telomeres and the role of these mechanisms in signalling short telomeres in the budding yeast Saccharomyces cerevisiae.
同源重组在正常长度的端粒序列中受到抑制。相比之下，当端粒酶活性缺失或由于核酶降解或不完全复制时，端粒会磨损，此时端粒重组是被允许的。在这里，我们综述了调控有丝分裂中端粒同源重组的机制，以及这些机制在芽殖酵母酿酒酵母中端粒短信号传递中的作用。
