内皮细胞陷窝和陷窝蛋白-1 作为动脉粥样硬化的关键调节因子。
Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis.
机构信息
Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
出版信息
Am J Pathol. 2010 Aug;177(2):544-6. doi: 10.2353/ajpath.2010.100247. Epub 2010 Jun 25.
Abstract
This commentary discusses the role of caveolin-1 in atherosclerosis.
摘要
本文述评了窖蛋白-1 在动脉粥样硬化中的作用。
相似文献
1
Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis.
Am J Pathol. 2010 Aug;177(2):544-6. doi: 10.2353/ajpath.2010.100247. Epub 2010 Jun 25.
2
Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease.
Curr Pharm Des. 2007;13(17):1761-9. doi: 10.2174/138161207780831202.
3
Caveolae and transcytosis in endothelial cells: role in atherosclerosis.
Cell Tissue Res. 2009 Jan;335(1):41-7. doi: 10.1007/s00441-008-0659-8. Epub 2008 Aug 8.
4
Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells.
Int J Mol Sci. 2023 May 17;24(10):8869. doi: 10.3390/ijms24108869.
5
Atherosclerosis, caveolae and caveolin-1.
Adv Exp Med Biol. 2012;729:127-44. doi: 10.1007/978-1-4614-1222-9_9.
6
Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent.
Toxicol Appl Pharmacol. 2009 May 15;237(1):1-7. doi: 10.1016/j.taap.2009.02.016. Epub 2009 Mar 2.
7
Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.
J Biol Chem. 2007 Jun 1;282(22):16631-43. doi: 10.1074/jbc.M607948200. Epub 2007 Apr 6.
8
Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.
Am J Pathol. 2010 Aug;177(2):998-1003. doi: 10.2353/ajpath.2010.091287. Epub 2010 Jun 25.
9
Role of caveolar compartmentation in endothelium-derived hyperpolarizing factor-mediated relaxation: Ca2+ signals and gap junction function are regulated by caveolin in endothelial cells.
Circulation. 2008 Feb 26;117(8):1065-74. doi: 10.1161/CIRCULATIONAHA.107.731679. Epub 2008 Feb 11.
10
Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice.
Microcirculation. 2010 Jan;17(1):32-8. doi: 10.1111/j.1549-8719.2009.00004.x.
引用本文的文献
1
Targeting Mitochondrial Dysfunction to Prevent Endothelial Dysfunction and Atherosclerosis in Diabetes: Focus on the Novel Uncoupler BAM15.
Int J Mol Sci. 2025 May 11;26(10):4603. doi: 10.3390/ijms26104603.
2
Genetic Manipulation of Caveolin-1 in a Transgenic Mouse Model of Aortic Root Aneurysm: Sex-Dependent Effects on Endothelial and Smooth Muscle Function.
Int J Mol Sci. 2024 Nov 26;25(23):12702. doi: 10.3390/ijms252312702.
3
Exploration of the Molecular Mechanism by Which Caveolin-1 Regulates Changes in Blood-Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis.
Trop Med Infect Dis. 2024 May 24;9(6):124. doi: 10.3390/tropicalmed9060124.
4
Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1.
JCI Insight. 2023 May 8;8(9):e165715. doi: 10.1172/jci.insight.165715.
5
Intracellular Membrane Transport in Vascular Endothelial Cells.
Int J Mol Sci. 2023 Mar 17;24(6):5791. doi: 10.3390/ijms24065791.
6
Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1.
Cells. 2022 Sep 28;11(19):3044. doi: 10.3390/cells11193044.
7
5,2'-Dibromo-2,4',5'-trihydroxydiphenylmethanone Inhibits LPS-Induced Vascular Inflammation by Targeting the Cav1 Protein.
Molecules. 2022 Apr 30;27(9):2884. doi: 10.3390/molecules27092884.
8
Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review.
Aging Dis. 2020 Mar 9;11(2):378-389. doi: 10.14336/AD.2019.09603. eCollection 2020 Apr.
9
Transmissible gastroenteritis virus infection decreases arginine uptake by downregulating CAT-1 expression.
Vet Res. 2018 Sep 20;49(1):95. doi: 10.1186/s13567-018-0591-1.
10
oxLDL-mediated cellular senescence is associated with increased NADPH oxidase p47phox recruitment to caveolae.
Biosci Rep. 2018 Jun 12;38(3). doi: 10.1042/BSR20180283. Print 2018 Jun 29.
本文引用的文献
1
Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice.
Am J Pathol. 2010 Aug;177(2):998-1003. doi: 10.2353/ajpath.2010.091287. Epub 2010 Jun 25.
2
Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis.
Cell Metab. 2009 Jul;10(1):48-54. doi: 10.1016/j.cmet.2009.06.003.
3
Transendothelial lipoprotein transport and regulation of endothelial permeability and integrity by lipoproteins.
Curr Opin Lipidol. 2009 Jun;20(3):197-205. doi: 10.1097/MOL.0b013e32832afd63.
4
Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress.
Biochim Biophys Acta. 2008 Oct;1783(10):1866-75. doi: 10.1016/j.bbamcr.2008.05.010. Epub 2008 May 23.
5
Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.
FASEB J. 2007 Sep;21(11):2970-9. doi: 10.1096/fj.07-8424com. Epub 2007 Apr 30.
6
Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy.
J Immunol. 2007 Feb 1;178(3):1505-11. doi: 10.4049/jimmunol.178.3.1505.
7
Short-term administration of a cell-permeable caveolin-1 peptide prevents the development of monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy.
Circulation. 2006 Aug 29;114(9):912-20. doi: 10.1161/CIRCULATIONAHA.106.634709.
8
Caveolin-1 and regulation of cellular cholesterol homeostasis.
Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H677-86. doi: 10.1152/ajpheart.01092.2005. Epub 2006 Apr 7.
9
Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway.
Am J Respir Cell Mol Biol. 2006 Apr;34(4):434-42. doi: 10.1165/rcmb.2005-0376OC. Epub 2005 Dec 15.
10
Decreased caveolin-1 in atheroma: loss of antiproliferative control of vascular smooth muscle cells in atherosclerosis.
Cardiovasc Res. 2005 Oct 1;68(1):128-35. doi: 10.1016/j.cardiores.2005.05.004.
Zotero 插件