Tian Jinfan, Popal Mohammad Sharif, Huang RongChong, Zhang Min, Zhao Xin, Zhang Mingduo, Song Xiantao
1 Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
2 Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Aging Dis. 2020 Mar 9;11(2):378-389. doi: 10.14336/AD.2019.09603. eCollection 2020 Apr.
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
小窝蛋白是小窝的一种结构蛋白，通过影响一氧化氮的活性和生物合成，以及调节介导炎症反应和氧化应激的信号转导通路，在调节内皮功能、细胞脂质稳态和心脏功能中发挥作用。在本综述中，我们阐述了小窝蛋白在心脏和血管疾病中的作用以及相关的信号通路。此外，我们还讨论了一种包括小窝蛋白与自噬之间相互作用的新型治疗前景。
