Raymond G G, Davis R L
College of Pharmacy, University of New Mexico, Albuquerque 87131.
DICP. 1991 Feb;25(2):123-6. doi: 10.1177/106002809102500202.
The physical compatibility and chemical stability of amphotericin B for injection USP (AB) admixed with magnesium sulfate injection USP (MS) in 5% dextrose injection USP (D5W) was evaluated. AB (final concentration of either 40 or 80 micrograms/mL of solution) and MS (final concentration of 0, 2, or 4 mg/mL of solution) were mixed in glass volumetric flasks containing D5W. AB concentration, as quantitated by high-performance liquid chromatography, and visible admixture clarity were monitored at zero, three, and six hours after combining with MS. At the three-hour observation, visible admixture clarity appeared to decrease in all multiple drug combinations and a clear supernatant began to develop as particulates settled to the bottom of the container. MS (final concentration of 4 or 8 mg/mL of solution) and AB (final concentration of 80 micrograms/mL of solution) were prepared in two separate intravenous polyvinyl chloride bags of D5W. The solutions were manually set to infuse via gravity for six hours and mix at the y-site of an intravenous administration set. Samples of the mixture were collected from the terminal end of a primary intravenous administration set at zero, two, four, and six hours after beginning the infusions. Each sample appeared visibly clear and maintained an AB concentration of at least 100 percent of the initial admixture concentration. MS and AB mixed in the same container appeared to be physically incompatible. The same admixture appeared to be physically compatible and chemically stable, in terms of AB, when infused as separate solutions mixed at a y-site of an intravenous administration set.
对注射用两性霉素B（AB）与硫酸镁注射液（MS）在5%葡萄糖注射液（D5W）中混合后的物理相容性和化学稳定性进行了评估。将AB（溶液终浓度为40或80微克/毫升）和MS（溶液终浓度为0、2或4毫克/毫升）在含有D5W的玻璃容量瓶中混合。在与MS混合后的0、3和6小时，通过高效液相色谱法定量测定AB浓度，并监测可见混合液的澄清度。在3小时观察时，所有多药组合的可见混合液澄清度似乎都降低了，随着微粒沉淀到容器底部，开始出现清澈的上清液。将MS（溶液终浓度为4或8毫克/毫升）和AB（溶液终浓度为80微克/毫升）分别配制在两个单独的含D5W的静脉用聚氯乙烯袋中。通过重力手动设置溶液输注6小时，并在静脉输液器的Y型接口处混合。在开始输注后的0、2、4和6小时，从一次静脉输液器的末端收集混合液样本。每个样本看起来明显澄清，且AB浓度保持在初始混合液浓度的至少100%。MS和AB在同一容器中混合似乎在物理上不相容。当作为在静脉输液器的Y型接口处混合的单独溶液输注时，就AB而言，相同的混合液在物理上似乎是相容的且化学上是稳定的。
