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Comparative study of four fluorescent probes for evaluation of natural killer cell cytotoxicity assays.用于评估自然杀伤细胞细胞毒性测定的四种荧光探针的比较研究。
Immunobiology. 2008;213(8):629-40. doi: 10.1016/j.imbio.2008.02.006. Epub 2008 Apr 28.
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Acute promyelocytic leukemia: from highly fatal to highly curable.急性早幼粒细胞白血病：从高度致命到高度可治愈。
Blood. 2008 Mar 1;111(5):2505-15. doi: 10.1182/blood-2007-07-102798.
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Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study.异基因干细胞移植后复发患者重复输注供体来源的细胞因子诱导杀伤细胞：一项I期研究。
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2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation.
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Why and how to quantify minimal residual disease in acute lymphoblastic leukemia?为什么以及如何量化急性淋巴细胞白血病中的微小残留病？
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Induction of tumor cell apoptosis via Fas/DR5.通过Fas/DR5诱导肿瘤细胞凋亡。
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Th1 polarization and apoptosis-inducing activity of CD4+ T -cells in cytokine-induced killers might favor the antitumor cytotoxicity of cytokine-induced killers in vivo.细胞因子诱导杀伤细胞中CD4+ T细胞的Th1极化和凋亡诱导活性可能有利于细胞因子诱导杀伤细胞在体内的抗肿瘤细胞毒性。
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反式肉桂醛对人白血病 K562 细胞的细胞毒性作用。

Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells.

机构信息

Center for Stem Cell Research and Application, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Acta Pharmacol Sin. 2010 Jul;31(7):861-6. doi: 10.1038/aps.2010.76. Epub 2010 Jun 28.

DOI:10.1038/aps.2010.76
PMID:20581850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4007726/
Abstract

AIM

To investigate the effects of trans-cinnamaldehyde (TCA) on the human leukemia K562 cell line and the cytotoxicity of cytokine-induced killer (CIK) cells against K562 cells.

METHODS

Apoptosis, Fas expression, and mitochondrial transmembrane potential in K652 cells were analyzed using flow cytometry. K562 cells were labeled with CFSE. The cytotoxic effect of expanded CIK cells on CFSE-labeled K562 cells was determined by FACS flow cytometry.

RESULTS

Treatment with TCA 180 micromol/L for 9 h induced apoptosis in 8.9%+/-1.23% of K562 cells. Treatment with 120 or 180 micromol/L TCA for 24 h significantly increased the apoptotic cells to 18.63%+/-1.42 % and 38.98%+/-2.74%, respectively. TCA significantly upregulates Fas expression and decreases mitochondrial transmembrane potential in K562 cells. TCA treatment at 120 and 180 micromol/L for 9 h enhanced the percentage of lysis of K562 cells by expanded CIK cells from 34.84%+/-2.13% to 48.21%+/-2.22 % and 64.81%+/-3.22% at the E:F ratio of 25:1 and from 49.26%+/-3.22% to 57.81%+/-5.13% and 73.36%+/-5.98% at E:F ratio of 50:1.

CONCLUSION

TCA exerts cytotoxic effects on human leukemia K562 cells by inducing apoptosis and synergizing the cytotoxicity of CIK cells against K562 cells. These properties of TCA are beneficial to the treatment of leukemia, even in the patients who have received hematopoietic stem cells transplantation (HSCT).

摘要

目的

研究反式肉桂醛（TCA）对人白血病 K562 细胞系的影响及细胞因子诱导的杀伤（CIK）细胞对 K562 细胞的细胞毒性。

方法

采用流式细胞术分析 K652 细胞凋亡、Fas 表达和线粒体跨膜电位。用 CFSE 标记 K562 细胞。用 FACS 流式细胞术测定扩增的 CIK 细胞对 CFSE 标记的 K562 细胞的细胞毒性作用。

结果

TCA 180 μmol/L 作用 9 h 可诱导 8.9%±1.23%的 K562 细胞发生凋亡，120 μmol/L 和 180 μmol/L TCA 作用 24 h 可使凋亡细胞分别增加到 18.63%±1.42%和 38.98%±2.74%。TCA 显著上调 K562 细胞 Fas 表达，降低线粒体跨膜电位。TCA 作用 9 h 时，在 E:F 比为 25:1 时，120 μmol/L 和 180 μmol/L TCA 可分别将扩增的 CIK 细胞对 K562 细胞的溶解率从 34.84%±2.13%提高到 48.21%±2.22%和 64.81%±3.22%，在 E:F 比为 50:1 时，可分别提高到 49.26%±3.22%、57.81%±5.13%和 73.36%±5.98%。

结论

TCA 通过诱导细胞凋亡对人白血病 K562 细胞发挥细胞毒性作用，并协同 CIK 细胞对 K562 细胞的细胞毒性作用。TCA 的这些特性有利于白血病的治疗，甚至对接受造血干细胞移植（HSCT）的患者也有益。