Karelin A A
Ontogenez. 1978;9(2):154-9.
The activity of enzymes of creatin biosynthesis in the rat liver and kidneys has been studied during the postnatal development. The activity of transamidinase of kidneys (E.C. 2.1.4.1.) increases gradually and linearly up to the 20th day after birth, then decreases on the 12th--25th days and increases again up to the level characteristic of the adult organism. The activity of guanidine acetate-N-methyl transferase (E.C. 2.1.1.2.) is rather high during the first days of postnatal development, then decreases and from the 15th day on increases again attaining the maximal level by the 23rd--25th day. The second period of the increase in the enzyme activity begins on the 29th--30th day of postnatal development. The results obtained suggest that the sharp increase of activity of guanidine acetate-N-methyl transferase of the rat liver during the early postnatal development is realized with the participation of cyclic 3',5'-AMP which appears to mediate the glucagon action.
在出生后的发育过程中，对大鼠肝脏和肾脏中肌酸生物合成酶的活性进行了研究。肾脏转脒基酶（E.C. 2.1.4.1.）的活性在出生后第20天前逐渐呈线性增加，然后在第12 - 25天下降，之后再次增加至成年生物体的特征水平。胍乙酸 - N - 甲基转移酶（E.C. 2.1.1.2.）的活性在出生后发育的最初几天相当高，然后下降，从第15天开始再次增加，到第23 - 25天达到最高水平。酶活性增加的第二个阶段始于出生后发育的第29 - 30天。所得结果表明，大鼠肝脏中胍乙酸 - N - 甲基转移酶在出生后早期发育期间活性的急剧增加是在环3',5'-AMP的参与下实现的，环3',5'-AMP似乎介导了胰高血糖素的作用。
