Karelin A A
Biokhimiia. 1977 May;42(5):833-8.
The activity of the enzyme of creatine biosynthesis, S-adenosylmethionine: guanidineacetate-N-methyltransferase (E. C. 2.1.1.2) is discovered in rat and bovine epiphysis homogenates. The enzyme activity was highest in epiphysis of immature and young rats and then decreased linearly with the animal age. No reliable activity of the enzyme was found in adult rats (200-300 g). Incubation of rat and bovine epiphysis with norepinephrine (10(-5)-10(-6) M) in the presence of S-adenosylmethionine and guanidineacetic acid resulted in the increase of the creatine synthesis rate.
在大鼠和牛的骨骺匀浆中发现了肌酸生物合成酶——S-腺苷甲硫氨酸：胍乙酸-N-甲基转移酶（E.C.2.1.1.2）的活性。该酶活性在未成熟和幼年大鼠的骨骺中最高，然后随动物年龄呈线性下降。在成年大鼠（200 - 300克）中未发现该酶的可靠活性。在S-腺苷甲硫氨酸和胍乙酸存在的情况下，用去甲肾上腺素（10⁻⁵ - 10⁻⁶ M）孵育大鼠和牛的骨骺，导致肌酸合成速率增加。
