结节病相关性肺动脉高压：阿拉伯患者的临床特征和结局。
Sarcoidosis-associated pulmonary hypertension: Clinical features and outcomes in Arab patients.
机构信息
Department of Medicine, Pulmonary Division, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
出版信息
Ann Thorac Med. 2010 Apr;5(2):86-91. doi: 10.4103/1817-1737.62471.
BACKGROUND
Pulmonary hypertension (PH) occurs in many patients with interstitial lung disease, including sarcoidosis. We explored the frequency, clinical characteristics and outcomes of PH in Arab patients diagnosed with pulmonary sarcoidosis.
METHODS
A retrospective study in three tertiary hospitals was performed on 96 patients who underwent Doppler echocardiography. Demographic and clinical characteristics, physiological studies and computed tomography (CT) results were collected, and compared between patients with and without PH.
RESULTS
Twenty (20.8%) patients were found to have PH. Patients with PH were more likely to be symptomatic (cough, P = 0.008; dyspnea, P = 0.04), to have an advanced radiographic stage (P = 0.001), and to be receiving systemic therapy (P = 0.001), compared to those without PH. Physiological data including pulmonary function test parameters, arterial blood gas levels and oxygen saturation at rest and after exercise were all significantly lower in patients with PH compared to those without PH. Comparison of CT patterns between patients with and without PH showed significant differences in the frequencies of ground-glass opacity (61.5 vs. 28.8%, P = 0.032) and fibrosis (76.9 vs. 44.2%, P = 0.035). In total, four patients died during the study period, including three with evidence of PH.
CONCLUSIONS
The frequency of PH in the present study was 20.8%. Clinical, physiologic and radiographic characteristics appeared to differentiate patients with PH from those without PH. The presence of PH contributed to poor outcomes in patients with pulmonary sarcoidosis.
背景
肺动脉高压（PH）发生于许多间质性肺疾病患者中，包括结节病。我们探讨了在被诊断为肺结节病的阿拉伯患者中 PH 的频率、临床特征和结局。
方法
对在三家三级医院接受多普勒超声心动图检查的 96 例患者进行了回顾性研究。收集了人口统计学和临床特征、生理研究和计算机断层扫描（CT）结果，并比较了有和无 PH 患者之间的差异。
结果
20 例（20.8%）患者存在 PH。与无 PH 患者相比，有 PH 的患者更可能有症状（咳嗽，P = 0.008；呼吸困难，P = 0.04），放射学分期更晚期（P = 0.001），并接受全身治疗（P = 0.001）。与无 PH 患者相比，有 PH 患者的生理数据，包括肺功能检查参数、动脉血气水平和静息及运动后氧饱和度均显著更低。有和无 PH 患者 CT 模式比较显示，磨玻璃影（61.5% vs. 28.8%，P = 0.032）和纤维化（76.9% vs. 44.2%，P = 0.035）的频率存在显著差异。研究期间共有 4 例患者死亡，其中 3 例有 PH 证据。
结论
本研究中 PH 的频率为 20.8%。临床、生理和放射学特征似乎可将 PH 患者与无 PH 患者区分开来。PH 的存在导致肺结节病患者的结局较差。
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