Department of Medicine, Division of Pulmonary Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Ann Thorac Med. 2009 Apr;4(2):60-4. doi: 10.4103/1817-1737.49414.
The 6-min walk test (6MWT) is a useful tool to assess prognosis and functional impairment in various pulmonary diseases.
To evaluate functional capacity during various stages of pulmonary sarcoidosis and develop a scoring system clinical radiological physiological score (CRP) that can potentially be used to assess the functional status among patients with sarcoidosis.
We performed a retrospective study on 26 patients diagnosed with pulmonary sarcoidosis from 2001 to 2007. All patients completed the 6MWT. The parameters assessed during the test included spirometry, arterial blood gas, 6-min walk distance (6MWD), Borg dyspnea score, and initial and end oxygen saturation.
Females covered a significantly shorter distance than males (343 m (223-389) vs. 416.5 m (352-500); P < 0.0001). In addition, females had a significantly lower SpO₂ at the end of the 6MWT than males (90.5 (61-99) vs. 96 (75-98); P < 0.03). The 6MWD was inversely correlated with the final Borg score (ρ = -0.603, P = 0.004) and the CRP score (ρ = -0.364, P = 0.047) and positively correlated with forced expiratory volume in 1 s (FEV₁) % ( ρ = 0.524, P = 0.006) and forced vital capacity (FVC) % (ρ = 0.407, P = 0.039).
Female gender, FEV₁%, final Borg score, FVC%, CRP score, and SpO₂ at the end of the 6MWT are associated with reduced 6MWD. It appears that Saudi patients diagnosed with sarcoidosis have a markedly reduced walking distance compared with other races. The effect of race and ethnicity and the utility of the CRP score as a potential marker to assess functional status require further exploration.
6 分钟步行测试（6MWT）是评估各种肺部疾病预后和功能障碍的有用工具。
评估不同阶段肺结节病的功能能力，并开发一种临床放射生理评分（CRP）评分系统，该系统可能用于评估结节病患者的功能状态。
我们对 2001 年至 2007 年间诊断为肺结节病的 26 例患者进行了回顾性研究。所有患者均完成了 6MWT。测试中评估的参数包括肺量计、动脉血气、6 分钟步行距离（6MWD）、Borg 呼吸困难评分以及初始和终末氧饱和度。
女性的步行距离明显短于男性（343m（223-389）vs. 416.5m（352-500）；P<0.0001）。此外，女性在 6MWT 结束时的 SpO₂明显低于男性（90.5（61-99）vs. 96（75-98）；P<0.03）。6MWD 与终末 Borg 评分（ρ=-0.603，P=0.004）和 CRP 评分（ρ=-0.364，P=0.047）呈负相关，与用力呼气量 1 秒百分比（FEV₁%）（ρ=0.524，P=0.006）和用力肺活量（FVC）%（ρ=0.407，P=0.039）呈正相关。
女性、FEV₁%、终末 Borg 评分、FVC%、CRP 评分和 6MWT 结束时的 SpO₂与 6MWD 降低相关。沙特患者诊断为结节病时，步行距离明显低于其他种族。种族和民族的影响以及 CRP 评分作为评估功能状态的潜在标志物的效用需要进一步探索。
Zotero 插件
