Quast U, Herder C, Zwisler O
Behringwerke AG, Drug Surveillance, Marburg, Germany.
Vaccine. 1991 Apr;9(4):228-30. doi: 10.1016/0264-410x(91)90104-e.
The aetiopathogenesis of Encephalomyelitis disseminata (multiple sclerosis) is not yet fully understood. It is thought to involve an immunopathological process, with various exogenic factors considered to be possibly responsible for inducing the disease or causing acute exacerbations. In the literature the following factors are described as having the capacity to interfere directly or indirectly in immunoregulatory mechanisms: infectious diseases, gravidity, various types of trauma, non-infectious diseases, and drugs, but also physical strain and vaccinations.
播散性脑脊髓炎(多发性硬化症)的发病机制尚未完全明了。人们认为它涉及免疫病理过程,各种外源性因素可能诱发该疾病或导致急性发作。文献中描述了以下因素有直接或间接干扰免疫调节机制的能力:传染病、妊娠、各类创伤、非传染病、药物,还有身体疲劳和疫苗接种。