p53、MDM2、p21、热休克蛋白 70 和 HPV 16/18 E6 蛋白在口腔疣状癌和口腔疣状增生中的表达。
Expression of p53, MDM2, p21, heat shock protein 70, and HPV 16/18 E6 proteins in oral verrucous carcinoma and oral verrucous hyperplasia.
机构信息
Graduate Institute of Clinical Dentistry and Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.
出版信息
Head Neck. 2011 Mar;33(3):334-40. doi: 10.1002/hed.21452.
BACKGROUND
Oral verrucous hyperplasia is a precancerous lesion of oral verrucous carcinoma.
METHODS
This study used immunohistochemistry to examine the expression of p53, murine double minute 2 (MDM2), p21, heat shock protein 70 (HSP 70), and human papillomavirus (HPV) 16/18 E6 proteins in 48 oral verrucous carcinoma and 30 oral verrucous hyperplasia samples.
RESULTS
The mean labeling indices of p53, MDM2, p21, HSP 70, and HPV 16/18 E6 proteins in oral verrucous carcinoma samples were 21%, 31%, 7%, 17%, and 0.5%, respectively, and those in oral verrucous hyperplasia samples were 19%, 35%, 11%, 14%, and 0.3%, respectively.
CONCLUSIONS
Immunohistochemistry with the above-cited 5 biomarkers could not help differentiate oral verrucous hyperplasia from oral verrucous carcinoma. The low expression of p21 may partially explain abnormal epithelial overgrowth in both verrucous lesions. The pathogenesis of both verrucous lesions may be at least partially attributed to the overexpression of MDM2 protein and moderate expression of HSP 70 protein in both lesions.
背景
口腔疣状增生是口腔疣状癌的癌前病变。
方法
本研究采用免疫组织化学方法检测 48 例口腔疣状癌和 30 例口腔疣状增生组织中 p53、鼠双微体 2（MDM2）、p21、热休克蛋白 70（HSP70）和人乳头瘤病毒（HPV）16/18 E6 蛋白的表达。
结果
口腔疣状癌组织中 p53、MDM2、p21、HSP70 和 HPV16/18 E6 蛋白的平均标记指数分别为 21%、31%、7%、17%和 0.5%，口腔疣状增生组织中分别为 19%、35%、11%、14%和 0.3%。
结论
上述 5 种生物标志物的免疫组织化学检测不能帮助区分口腔疣状增生和口腔疣状癌。p21 的低表达可能部分解释了两种疣状病变中上皮过度生长的异常。两种疣状病变的发病机制至少部分归因于 MDM2 蛋白的过表达和两种病变中 HSP70 蛋白的中度表达。
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