Department of Otorhinolaryngology, General Hospital Dr. Franc Derganc Nova Gorica, Šempeter pri Gorici, Ljubljana Slovenia.
Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Radiol Oncol. 2023 Mar 22;57(1):1-11. doi: 10.2478/raon-2023-0015. eCollection 2023 Mar 1.
Verrucous carcinoma is a low-grade variant of squamous cell carcinoma with specific morphologic, cytokinetic and clinical features. Despite low mitotic activity and slow growth, it can infiltrate adjacent tissues in advanced stages but does not metastasize. The most frequently affected site is the oral cavity. The following article provides latest updates in the etiology, clinical presentation, diagnostics and treatment options in oral verrucous carcinoma and discusses the existing dilemmas linked to this unique malignancy.
Oral verrucous carcinoma must be differentiated from conventional squamous cell carcinoma due to its less aggressive behaviour with a more favourable prognosis. Close communication between clinician and pathologist is mandatory for making a correct diagnosis. Primary surgery with negative surgical margins seems to be the most successful treatment. However, management recommendations are not uniform since they are mostly based on case reports and small retrospective case series. Prospective and pooled multi-institutional studies are therefore needed.
疣状癌是一种低级别鳞状细胞癌，具有特定的形态、细胞动力学和临床特征。尽管有低有丝分裂活性和缓慢的生长速度，但在晚期仍可浸润邻近组织，但不会转移。最常受影响的部位是口腔。本文提供了口腔疣状癌在病因、临床表现、诊断和治疗选择方面的最新进展，并讨论了与这种独特恶性肿瘤相关的现有困境。
口腔疣状癌的行为不如普通鳞状细胞癌具有侵袭性，预后较好，因此必须与其相区别。临床医生和病理学家之间必须密切沟通，以做出正确的诊断。原发肿瘤切除且切缘阴性似乎是最成功的治疗方法。然而，由于这些建议主要基于病例报告和小型回顾性病例系列，因此管理建议并不统一。因此，需要前瞻性和多机构的研究。
