从火木层孔菌培养物中分离得到的同型和庚型甾醇及震颤烷倍半萜。

Homo- and heptanor-sterols and tremulane sesquiterpenes from cultures of Phellinus igniarius.

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing, People's Republic of China.

出版信息

J Nat Prod. 2010 Jul 23;73(7):1294-300. doi: 10.1021/np100216k.

DOI:10.1021/np100216k

PMID:20583752

Abstract

Four steroids, a homopregnene (1) and three heptanorergosterane derivatives (2-4), nine tremulane sesquiterpenes (5-13), and 18 known compounds have been isolated from cultures of the fungus Phellinus igniarius. Their structures and absolute configurations were elucidated by spectroscopic data analysis. In preliminary in vitro assays, at 10(-5) M, compounds 8, 9, 13, and 3beta-hydroxy-11,12-O-isopropyldrimene (14) showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 35.7%, 45.4%, 46.6%, and 32.1%, respectively, as compared with the blank control.

摘要

从火木层孔菌(Phellinus igniarius)的发酵液中分离得到了 4 种甾体化合物、1 种同孕烯(1)和 3 种羊毛甾烷衍生物(2-4)、9 种松三萜烯(5-13)以及 18 种已知化合物。通过光谱数据分析阐明了它们的结构和绝对构型。在初步的体外试验中，化合物 8、9、13 和 3β-羟基-11,12-O-异亚丙基二氢松香烯(14)在 10(-5) M 浓度下对由苯肾上腺素引起的血管收缩显示出显著的血管舒张活性，其舒张率分别为 35.7%、45.4%、46.6%和 32.1%，与空白对照相比。