朝着具有明确结构的壳寡糖的模块化合成迈进：四种壳二糖的合成。
Towards a modular synthesis of well-defined chitooligosaccharides: synthesis of the four chitodisaccharides.
机构信息
Laboratoire des Matériaux Polymères et des Biomatériaux, Ingénierie des Matériaux Polymères, UMR CNRS 5223, Université Lyon 1, Domaine scientifique de La Doua, Bât. ISTIL, 15 Bd Latarjet, F-69622 Villeurbanne Cedex, France.
出版信息
Carbohydr Res. 2010 Aug 16;345(12):1685-97. doi: 10.1016/j.carres.2010.05.010. Epub 2010 May 19.
The total chemical synthesis of the four well-defined chitodisaccharides is described using N-trichloroacetyl (TCA) and N-benzyloxycarbonyl (Z) as C-2 protecting groups for acetamido and free amino groups, respectively. The synthesis is carried out according to a strategy that paves way to the elaboration of various homo- and hetero-chitooligosaccharides, with perfect control of the number and the position of GlcN and GlcNAc units along the oligomer chain.
本文描述了使用 N-三氯乙酰基（TCA）和 N-苄氧羰基（Z）作为 C-2 乙酰氨基和游离氨基的保护基团，对四种结构明确的壳二糖进行全化学合成。该合成策略为各种同型和异型壳寡糖的制备铺平了道路，可精确控制寡糖链上 GlcN 和 GlcNAc 单元的数量和位置。
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