Carvalho Luísa C R, Queda Fausto, Santos Cátia V Almeida, Marques M Manuel B
LAQV@REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516, Caparica, Portugal.
Chem Asian J. 2016 Dec 19;11(24):3468-3481. doi: 10.1002/asia.201601041. Epub 2016 Nov 23.
Chitin and chitosan are attractive biopolymers with enormous structural possibilities for chemical modification, creating platforms for new chemical entities with a broad scope of applications, ranging from material science to medicine. During the last few years, incredible efforts have been dedicated to the regioselective modification of these biopolymers paving the way for improved properties and tailored activities. Herein, the most recent advances in chitin/chitosan regioselective modification, reaction conditions, selectivity, and the impact on its applications are highlighted. Moreover, the recent focus on chitooligosaccharides, their regioselective and chemoselective functionalization, as well as their role in biological studies, including molecular recognition with several biological targets are also covered.
几丁质和壳聚糖是具有吸引力的生物聚合物，在化学修饰方面具有巨大的结构可能性，为新型化学实体创造了平台，其应用范围广泛，从材料科学到医学。在过去几年中，人们为这些生物聚合物的区域选择性修饰付出了巨大努力，为改善性能和定制活性铺平了道路。本文重点介绍了几丁质/壳聚糖区域选择性修饰、反应条件、选择性及其对应用的影响方面的最新进展。此外，还涵盖了对壳寡糖的最新关注、它们的区域选择性和化学选择性功能化，以及它们在生物学研究中的作用，包括与多个生物靶点的分子识别。
