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壳聚糖衍生物与水杨酸及其片段的免疫调节活性

[Immunomodulating activity of chitosan derivatives with salicylic acid and its fragments].

作者信息

Vasiukova N I, Ozeretskovskaia O L, Chalenko G I, Gerasimova N G, L'vova A A, Il'ina A V, Levov A N, Varlamov V P, Tarchevskiĭ I A

出版信息

Prikl Biokhim Mikrobiol. 2010 May-Jun;46(3):379-84.

PMID:20586293
Abstract

A study of biological activity of the derivatives of the chitin-chitosan oligomer with salicylic acid and its fragments showed that chitosan salicylate actively protected potato tubers against Phytophthora infestans but sharply inhibited reparation of potato tissues. N-(2-Hydroxybenzyl)chitosan exhibited good protective properties but did not influence wound reparation. N-(2-Hydroxy-3-methoxybenzyl)-N-pyridox-chitosan, which contained the pyridoxal and 2-hydroxy-3-methoxy fragments, was the most efficient, stimulating both defense against late blight and wound reparation in potato tissues.

摘要

一项关于几丁质-壳聚糖低聚物与水杨酸及其片段衍生物的生物活性研究表明,壳聚糖水杨酸盐能有效保护马铃薯块茎免受致病疫霉侵害,但会显著抑制马铃薯组织的修复。N-(2-羟基苄基)壳聚糖具有良好的保护性能,但对伤口修复没有影响。含有吡哆醛和2-羟基-3-甲氧基片段的N-(2-羟基-3-甲氧基苄基)-N-吡哆壳聚糖最为有效,既能刺激马铃薯组织对晚疫病的防御,又能促进伤口修复。

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