Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Am J Clin Dermatol. 2010;11 Suppl 1:11-3. doi: 10.2165/1153414-S0-000000000-00000.
Psoriasis is a chronic inflammatory disease of the skin and joints that typically follows a relapsing/remitting disease course. Whereas psoriasis is primarily a T-cell-mediated disease, intrinsic alterations in epidermal keratinocytes also play an important role. Tumor necrosis factor alpha (TNFalpha) has been identified as an important cytokine in the inflammatory cascade of psoriasis. The importance of TNFalpha is further underlined by the therapeutic efficacy of compounds that interfere with TNFalpha function, such as biological agents.
银屑病是一种慢性炎症性皮肤病和关节病，通常遵循复发/缓解的疾病过程。虽然银屑病主要是一种 T 细胞介导的疾病，但表皮角质形成细胞的内在改变也起着重要作用。肿瘤坏死因子 α（TNFalpha）已被确定为银屑病炎症级联反应中的重要细胞因子。干扰 TNFalpha 功能的化合物（如生物制剂）具有治疗效果，这进一步强调了 TNFalpha 的重要性。
