Guenther Lyn C
Division of Dermatology, University of Western Ontario, London, ON, Canada.
Skin Therapy Lett. 2011 Jun;16(6):1-3.
Although biologics are very efficacious as monotherapy in patients with psoriasis, combination treatment with traditional systemic and topical therapies may increase the speed of onset and enhance efficacy without significant additional toxicity. In contrast, in psoriatic arthritis, the addition of methotrexate to anti-tumour necrosis factor-alpha therapy does not enhance efficacy in either the skin or joints.
尽管生物制剂作为单一疗法对银屑病患者非常有效，但与传统的全身和局部疗法联合使用可能会加快起效速度并提高疗效，且不会增加显著的额外毒性。相比之下，在银屑病关节炎中，在抗肿瘤坏死因子-α治疗中添加甲氨蝶呤并不会增强皮肤或关节的疗效。
