Moccia Krinon D, Olsen Cara H, Mitchell Jennifer M, Landauer Michael R
Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
J Am Assoc Lab Anim Sci. 2010 May;49(3):323-8.
Concern regarding the potential for radiation exposure from accidents or nuclear and radiologic terrorism is increasing. The purpose of this study was to determine whether the addition of minimal supportive care consisting of hydration or nutritional gels could be used to reduce mortality in mice exposed to (60)Co gamma-radiation. Male CD2F1 mice received 0, 8.50, or 9.25 Gy (60)Co at a dose rate of 0.6 Gy/min. These groups were further divided into 3 treatment groups that-in addition to pelleted food and water-received no supportive care, hydration gel, or nutritional gel. Overall survival, mean survival time, consumption of pelleted food and gel, and body weight were recorded for 30 d. Radiation caused dose-dependent decreases in overall survival, consumption of pelleted food and supplemental gel, and body weight. However, at each radiation dose (0, 8.50, 9.25 Gy), the type of supportive care did not modify overall survival, mean survival time, or changes in body weight. These results demonstrate that hydration and nutritional gels were not effective methods of supportive care after high-dose total body irradiation in mice.
人们对事故或核与放射恐怖主义导致辐射暴露的可能性的担忧日益增加。本研究的目的是确定添加由水合作用或营养凝胶组成的最低限度支持性护理是否可用于降低接受（60）Coγ射线辐射的小鼠的死亡率。雄性CD2F1小鼠以0.6 Gy/min的剂量率接受0、8.50或9.25 Gy的（60）Co辐射。这些组进一步分为3个治疗组，除了颗粒食物和水之外，分别不接受支持性护理、水合凝胶或营养凝胶。记录30天的总体生存率、平均生存时间、颗粒食物和凝胶的消耗量以及体重。辐射导致总体生存率、颗粒食物和补充凝胶的消耗量以及体重呈剂量依赖性下降。然而，在每个辐射剂量（0、8.50、9.25 Gy）下，支持性护理的类型并未改变总体生存率、平均生存时间或体重变化。这些结果表明，水合作用和营养凝胶在小鼠高剂量全身照射后不是有效的支持性护理方法。
