Nakai K, Kojima T, Hattori K, Miyachi S, Ishihara M, Kobayashi N, Okamoto T, Yoshida J
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya; Japan.
Interv Neuroradiol. 2004 Dec 24;10 Suppl 2(Suppl 2):95-100. doi: 10.1177/15910199040100S217. Epub 2008 May 15.
The purpose of this study was to evaluate the feasibility of photocrosslinkable chitosan as an embolization material for aneurysms. Three experimental aneurysms were created in three Japanese white rabbits. All of the aneurysms were packed with chitosan hydrogel. Histopathologic data were analyzed on two, seven, and 30 days after embolization. Unorganized clots and minimal inflammation around the applied chitosan hydrogel were observed two days after implantation. After seven days, the chitosan was reduced and inflammatory response appeared. At 30 days, most of the aneurysm lumen was replaced with inflammatory cells, and the remaining chitosan was not observed. Severe complications such as anaphylaxis did not occur after the embolization with the chitosan. These results suggest that photocrosslinkable chitosan might be a candidate for an embolization material for endovascular treatment of cerebral aneurysms.
本研究的目的是评估可光交联壳聚糖作为动脉瘤栓塞材料的可行性。在三只日本白兔身上制造了三个实验性动脉瘤。所有动脉瘤均用壳聚糖水凝胶填充。在栓塞后第2天、第7天和第30天对组织病理学数据进行分析。植入后第2天观察到应用的壳聚糖水凝胶周围有无组织的凝块和轻微炎症。7天后，壳聚糖减少，炎症反应出现。在第30天，大部分动脉瘤腔被炎性细胞取代，未观察到残留的壳聚糖。用壳聚糖栓塞后未发生过敏反应等严重并发症。这些结果表明，可光交联壳聚糖可能是用于脑动脉瘤血管内治疗的栓塞材料的候选者。
