Wang Y, Xu N, Luo Q, Li Y, Sun L, Wang H, Xu K, Wang B, Zhen Y
First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
Interv Neuroradiol. 2011 Mar;17(1):87-92. doi: 10.1177/159101991101700114. Epub 2011 Apr 29.
We sought to assess the feasibility of using thermosensitive chitosan/β-glycerophosphate forembolotherapy. The renal arteries in nine rabbits were embolized with chitosan/β-glycero-phosphate. The animals were studied angiographically and sacrificed at one week (n = 3), four weeks (n = 3), and eight weeks (n = 3) after embolotherapy. Histology was obtained at these three time points. Delivery of chitosan/β-glycerophosphate was successful in all cases. Complete occlusion was achieved in all cases. No recanalization was observed in the follow-up angiograms. No untoward inflammatory reactions were observed in the target renal arteries and infarcted kidneys during the histological examinations. Our preliminary feasibility evaluation in rabbit renal arteries indicates that C/GP is a satisfactory embolization agent.
我们试图评估使用热敏壳聚糖/β-甘油磷酸酯进行栓塞治疗的可行性。用壳聚糖/β-甘油磷酸酯栓塞了9只兔子的肾动脉。在栓塞治疗后1周（n = 3）、4周（n = 3）和8周（n = 3）对动物进行血管造影研究并处死。在这三个时间点获取组织学样本。壳聚糖/β-甘油磷酸酯的输送在所有病例中均成功。所有病例均实现了完全闭塞。在随访血管造影中未观察到再通。在组织学检查期间，在目标肾动脉和梗死肾中未观察到不良炎症反应。我们在兔肾动脉中的初步可行性评估表明，C/GP是一种令人满意的栓塞剂。
