Yoshimura S, Kaku Y, Kokuzawa J, Hayashi K, Sakai N
Department of Neurosurgery, Gifu University School of Medicine, Gifu; Japan.
Interv Neuroradiol. 2004 Mar 30;10 Suppl 1(Suppl 1):63-6. doi: 10.1177/15910199040100S108. Epub 2008 Jun 9.
Percutaneous transluminal angioplasty (PTA) has been a useful therapy to treat stenosis of cervical internal carotid artery (ICA) or vertebral artery (VA). Here we show that our clinical results regarding preventive effect of stenting on restenosis after PTA in the ICA and VA origin. We also show our experimental studies with gene transfer techniques aiming reduction of restenosis after balloon-injury in rat carotid artery. It has been reported that drug-eluting stent inhibits restenosis after coronary angioplasty. Further understanding of the mechanism of restenosis and application of these new modalities may lead to better clinical results in angioplasty of the craniocervical arteries.
经皮腔内血管成形术（PTA）一直是治疗颈内动脉（ICA）或椎动脉（VA）狭窄的有效方法。在此我们展示了关于支架置入对ICA和VA起始部PTA后再狭窄预防效果的临床结果。我们还展示了利用基因转移技术旨在减少大鼠颈动脉球囊损伤后再狭窄的实验研究。据报道，药物洗脱支架可抑制冠状动脉成形术后的再狭窄。对再狭窄机制的进一步理解以及这些新方法的应用可能会在颅颈动脉成形术中带来更好的临床效果。
