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本文引用的文献

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Results and problems in percutaneous transluminal angioplasty for internal carotid artery stenosis.
Interv Neuroradiol. 1998 Nov 30;4 Suppl 1:37-40. doi: 10.1177/15910199980040S105. Epub 2001 May 15.
2
Drug-eluting stents in vascular intervention.血管介入治疗中的药物洗脱支架
Lancet. 2003 Jan 18;361(9353):247-9. doi: 10.1016/S0140-6736(03)12275-1.
3
A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization.西罗莫司洗脱支架与标准支架用于冠状动脉血运重建的随机对照研究。
N Engl J Med. 2002 Jun 6;346(23):1773-80. doi: 10.1056/NEJMoa012843.
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Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element 'decoy' of nuclear factor-kappaB binding site as a novel molecular strategy.以核因子-κB结合位点的顺式元件“诱饵”作为一种新的分子策略抑制大鼠颈动脉球囊损伤后的内膜增生。
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Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up.西罗莫司洗脱支架对新生内膜增殖的持续抑制作用：一年血管造影和血管内超声随访
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Global experience in cervical carotid artery stent placement.全球颈总动脉支架置入经验。
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7
Activation of the NF-kappa B and I kappa B system in smooth muscle cells after rat arterial injury. Induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1.大鼠动脉损伤后平滑肌细胞中NF-κB和IκB系统的激活。血管细胞黏附分子-1和单核细胞趋化蛋白-1的诱导。
Am J Pathol. 1997 Oct;151(4):1085-95.
8
Elective stenting of the extracranial carotid arteries.颅外颈动脉选择性支架置入术。
Circulation. 1997 Jan 21;95(2):376-81. doi: 10.1161/01.cir.95.2.376.
9
Vertebral artery stenting following percutaneous transluminal angioplasty. Technical note.经皮腔内血管成形术后椎动脉支架置入术。技术说明。
J Neurosurg. 1996 May;84(5):883-7. doi: 10.3171/jns.1996.84.5.0883.
10
Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.活化转录因子核因子-κB存在于动脉粥样硬化病变中。
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经皮腔内血管成形术后再狭窄的预防策略。临床与基础方法。

Strategy for Prevention of Restenosis after PTA. Clinical and Basic Approaches.

作者信息

Yoshimura S, Kaku Y, Kokuzawa J, Hayashi K, Sakai N

机构信息

Department of Neurosurgery, Gifu University School of Medicine, Gifu; Japan.

出版信息

Interv Neuroradiol. 2004 Mar 30;10 Suppl 1(Suppl 1):63-6. doi: 10.1177/15910199040100S108. Epub 2008 Jun 9.

DOI:10.1177/15910199040100S108
PMID:20587274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3490176/
Abstract

Percutaneous transluminal angioplasty (PTA) has been a useful therapy to treat stenosis of cervical internal carotid artery (ICA) or vertebral artery (VA). Here we show that our clinical results regarding preventive effect of stenting on restenosis after PTA in the ICA and VA origin. We also show our experimental studies with gene transfer techniques aiming reduction of restenosis after balloon-injury in rat carotid artery. It has been reported that drug-eluting stent inhibits restenosis after coronary angioplasty. Further understanding of the mechanism of restenosis and application of these new modalities may lead to better clinical results in angioplasty of the craniocervical arteries.

摘要

经皮腔内血管成形术（PTA）一直是治疗颈内动脉（ICA）或椎动脉（VA）狭窄的有效方法。在此我们展示了关于支架置入对ICA和VA起始部PTA后再狭窄预防效果的临床结果。我们还展示了利用基因转移技术旨在减少大鼠颈动脉球囊损伤后再狭窄的实验研究。据报道，药物洗脱支架可抑制冠状动脉成形术后的再狭窄。对再狭窄机制的进一步理解以及这些新方法的应用可能会在颅颈动脉成形术中带来更好的临床效果。