Storey G S, Marks M P, Dake M, Norbash A M, Steinberg G K
Department of Radiology, Stanford University Medical Center, California, USA.
J Neurosurg. 1996 May;84(5):883-7. doi: 10.3171/jns.1996.84.5.0883.
The authors report initial results and follow up using stent placement to treat atherosclerotic stenosis in vertebral arteries. Three patients with severe atherosclerotic vascular disease underwent vertebral artery stent placement using a balloon expandable stent. Medical therapy (aspirin and warfarin) and conventional percutaneous angioplasty failed to resolve the disease and the patients developed symptomatic restenosis within 3 months of angioplasty. Two patients had symptoms of anterior circulation ischemia with carotid artery occlusions and reduced supply to the anterior circulation from the stenosed vertebral arteries. One patient had recurrent posterior circulation symptoms. Stents were successfully placed in all three, resulting in immediate reversal of stenosis and resolution of symptoms. Clinical follow-up study (mean 9 months) has shown no recurrent symptoms in the patient with posterior circulation symptoms, but the two patients with anterior circulation ischemia did develop recurrent symptoms. Angiographic follow up in these two patients at 3 months and 1 year, however, demonstrated continued patency of vertebral artery lumina. They underwent extracranial-intracranial bypass surgery to relieve their symptoms. This experience suggests stents can be placed without complication in the proximal vertebral arteries and may have an adjunctive role in the treatment of atherosclerotic cerebrovascular disease following unsuccessful angioplasty.
作者报告了使用支架置入术治疗椎动脉粥样硬化性狭窄的初步结果及随访情况。3例患有严重动脉粥样硬化性血管疾病的患者接受了使用球囊扩张支架的椎动脉支架置入术。药物治疗(阿司匹林和华法林)及传统经皮血管成形术未能解决该疾病,且患者在血管成形术后3个月内出现了有症状的再狭窄。2例患者出现前循环缺血症状,伴有颈动脉闭塞,且来自狭窄椎动脉的前循环供血减少。1例患者有后循环症状复发。3例患者均成功置入支架,狭窄立即得到缓解,症状消失。临床随访研究(平均9个月)显示,有后循环症状的患者未出现症状复发,但2例有前循环缺血的患者确实出现了症状复发。然而,这2例患者在3个月和1年时的血管造影随访显示椎动脉管腔持续通畅。他们接受了颅外-颅内搭桥手术以缓解症状。这一经验表明,支架可无并发症地置入椎动脉近端,并且在血管成形术失败后的动脉粥样硬化性脑血管疾病治疗中可能起辅助作用。