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Interv Neuroradiol. 2004 Mar 30;10 Suppl 1(Suppl 1):67-9. doi: 10.1177/15910199040100S109. Epub 2008 Jun 9.
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Selective removal of cholesterol esters in an arteriosclerotic region of blood vessels with a free-electron laser.
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红外自由电子激光血管内治疗的研发。选择性去除颈动脉粥样斑块中的胆固醇酯。

Development of an intravascular laser treatment with an infrared free electron laser. Selective removal of cholesterol ester in carotid atheromatous plaques.

作者信息

Nakajima Y, Iwatsuki K, Ishii K, Fujinaka T, Awazu K, Yoshimine T

机构信息

Dept of Neurosurgery, Osaka University Medical School and Institute of Free Electron Laser; Japan.

出版信息

Interv Neuroradiol. 2004 Mar 30;10 Suppl 1(Suppl 1):67-9. doi: 10.1177/15910199040100S109. Epub 2008 Jun 9.

DOI:10.1177/15910199040100S109
PMID:20587275
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3490177/
Abstract

We have studied to develop an intravascular device with an infrared free electron laser (FEL) to treat occlusive carotid atherosclerotic lesions. In this study, we irradiated the FEL with a wavelength of 5.75 mum on surgical specimens of human atheromatous carotid plaques. After the irradiation on a cholesterol-ester-accumulated portion of the carotid plaques under proper conditions, a microscope transmission FTIR (Fourier Transform Infrared) spectroscopy showed that the peak of a tissue infrared absorption spectrum corresponding to the molecular vibration of cholesterol ester (5.75 mum) disappeared.Tissue damages associated with the irradiation were not histologically noted. This study demonstrated that irradiation of FEL can selectively remove cholesterol ester from the human atheromatous carotid plaques.

摘要

我们已开展研究，以开发一种配备红外自由电子激光（FEL）的血管内装置，用于治疗颈动脉闭塞性动脉粥样硬化病变。在本研究中，我们用波长为5.75微米的FEL照射人动脉粥样硬化颈动脉斑块的手术标本。在适当条件下对颈动脉斑块中胆固醇酯积聚部分进行照射后，显微镜透射傅里叶变换红外（FTIR）光谱显示，对应于胆固醇酯分子振动（5.75微米）的组织红外吸收光谱峰消失。组织学上未发现与照射相关的组织损伤。本研究表明，FEL照射可选择性地从人动脉粥样硬化颈动脉斑块中去除胆固醇酯。