治疗性蛋白质的免疫原性。
The immunogenicity of therapeutic proteins.
作者信息
Schellekens Huub
机构信息
Department of Pharmaceutical Sciences and Department of Innovation Studies, Utrecht University, Rotterdam, Netherlands.
出版信息
Discov Med. 2010 Jun;9(49):560-4.
PMID:20587346
Abstract
Nearly all therapeutic proteins induce antibodies in patients. However this immunogenicity has been neglected in the use of these products, even though the antibodies may have severe consequences. During the last few years, progress has been made in understanding why patients do not tolerate these protein therapeutic products and also how to manage the problem of immunogenicity.
摘要
几乎所有治疗性蛋白质都会在患者体内诱导产生抗体。然而，在这些产品的使用过程中，这种免疫原性一直被忽视，尽管这些抗体可能会产生严重后果。在过去几年里，在理解患者为何不能耐受这些蛋白质治疗产品以及如何处理免疫原性问题方面已经取得了进展。
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