Newman P L, Fletcher C D
Department of Histopathology, St. Thomas's Hospital, London, England.
Am J Surg Pathol. 1991 Jul;15(7):607-14. doi: 10.1097/00000478-199107000-00001.
Malignant mesenchymoma is a rare soft tissue neoplasm which, by definition, shows at least two distinct types of frankly malignant mesenchymal differentiation in addition to any "undifferentiated" or "fibrosarcomatous" areas. It is generally regarded as a high-grade tumor. A series of nine new cases is presented in which all patients except one were adults. Four tumors arose in the retroperitoneum, three in the thigh. The only definable constituents were rhabdomyosarcoma (eight cases), liposarcoma (seven cases), and osteo/chondrosarcoma (five cases). On histologic grounds, at least one element in each case would normally be regarded as high grade. Of six cases with a median follow-up of 4.2 years, only one has died from tumor. One further case was an incidental postmortem finding. In contrast to most current opinion, these data suggest that malignant mesenchymoma is not as aggressive as the histology would imply.
恶性间叶瘤是一种罕见的软组织肿瘤，根据定义，除了任何“未分化”或“纤维肉瘤样”区域外，它至少显示出两种明显不同类型的明显恶性间叶分化。它通常被认为是一种高级别肿瘤。本文报告了9例新病例，其中除1例患者外均为成年人。4例肿瘤发生于腹膜后，3例发生于大腿。唯一可明确的成分是横纹肌肉瘤（8例）、脂肪肉瘤（7例）和骨/软骨肉瘤（5例）。从组织学角度看，每例中至少有一种成分通常会被视为高级别。6例患者的中位随访时间为4.2年，只有1例死于肿瘤。另有1例是尸检时偶然发现的。与目前大多数观点相反，这些数据表明恶性间叶瘤并不像组织学所暗示的那样具有侵袭性。
