恶性间叶瘤
Malignant mesenchymoma.
作者信息
Brady M S, Perino G, Tallini G, Russo P, Woodruff J M
机构信息
Department of Surgery Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
出版信息
Cancer. 1996 Feb 1;77(3):467-73. doi: 10.1002/(SICI)1097-0142(19960201)77:3<467::AID-CNCR7>3.0.CO;2-H.
BACKGROUND
Malignant mesenchymomas are rare soft tissue tumors that contain two or more distinct histologic subtypes of sarcoma within the same tumor (exclusive of a fibrosarcomatous or hemangiopericytomatous component). They are generally considered high grade neoplasms and are associated with a poor prognosis, although experience with these tumors is limited.
METHODS
We report 8 patients seen at our center over the last 22 years and describe the clinical course of a patient with a malignant mesenchymoma arising in the retroperitoneum whose experience typifies the aggressive behavior of this tumor.
RESULTS
All eight patients had large, high grade tumors located in the retroperitoneum or thigh. Six of the 8 died of disease and 2 were alive with disease at a median of 30 months from diagnosis.
CONCLUSIONS
Malignant mesenchymoma represents a particularly aggressive form of soft tissue sarcoma. Our experience with this disease highlights the need for more effective treatment strategies for these patients.
背景
恶性间叶瘤是一种罕见的软组织肿瘤，在同一肿瘤内包含两种或更多不同组织学亚型的肉瘤（不包括纤维肉瘤或血管外皮细胞瘤成分）。尽管对这些肿瘤的经验有限，但它们通常被认为是高级别肿瘤，且预后较差。
方法
我们报告了过去22年在我们中心诊治的8例患者，并描述了1例起源于腹膜后的恶性间叶瘤患者的临床病程，该患者的经历体现了这种肿瘤的侵袭性。
结果
所有8例患者均有位于腹膜后或大腿的大的高级别肿瘤。8例中有6例死于疾病，2例在诊断后中位30个月时仍患有疾病存活。
结论
恶性间叶瘤是软组织肉瘤中一种特别具有侵袭性的形式。我们对这种疾病的经验凸显了为这些患者制定更有效治疗策略的必要性。
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