Pavlova T A, Shalina R I, Kazakova L E, Egorov D Iu, Azizova O A
Akush Ginekol (Mosk). 1991 Mar(3):37-40.
Serum and red blood cell membrane lipid peroxidation (LPO), antioxidative activity (AOA) of the ceruloplasmin/transferrin (CP/TF) system, and biophysical parameters of the structure of a red blood cell membrane lipid bilayer were examined in fetuses experienced acute hypoxia at birth and in babies born to healthy mothers with uncomplicated pregnancy. The intensity of LPO product accumulation in mild asphyxia was ascertained to be proportional to the duration of hypoxic exposure of a fetus. In severe asphyxia accompanied by lower formation of primary LPO products, the levels of secondary LPO products showed a rise. A slight increase of AOA in the CP/TF system was unable to adequately compensate a high intensity of LPO processes, which provides strong evidence for altered structural parameters in the lipid bilayer. It was concluded that it was essential to correct hypoxic states in children with antioxidants immediately after birth.
对出生时经历急性缺氧的胎儿以及妊娠过程正常的健康母亲所生婴儿的血清和红细胞膜脂质过氧化（LPO）、铜蓝蛋白/转铁蛋白（CP/TF）系统的抗氧化活性（AOA）以及红细胞膜脂质双层结构的生物物理参数进行了检测。已确定轻度窒息时LPO产物积累的强度与胎儿缺氧暴露的持续时间成正比。在伴有初级LPO产物形成减少的重度窒息中，次级LPO产物水平升高。CP/TF系统中AOA的轻微增加无法充分补偿LPO过程的高强度，这为脂质双层结构参数的改变提供了有力证据。得出的结论是，出生后应立即用抗氧化剂纠正儿童的缺氧状态。
