Ponomarev A T
Probl Endokrinol (Mosk). 1978 Jan-Feb;24(1):68-72.
In this clinico-experimental work data are presented concerning the blood plasma insulin activity in mature fetuses and neonates in asphyxia; the influence of insulin on the course of hypoxia and elimination of its sequelae under experimental conditions on the newborn and sexually mature rats was also noted. The blood plasma insulin activity proved to increase in the neonates born of mothers with normally coursing pregnancy. A statistically significant reduction of the insulin activity was noted in neonates whose mothers suffered from toxemia of the second half of pregnancy. The death of fetuses and neonates was accompanied by a marked reduction of the blood plasma insulin activity. Preliminary administration of insulin increased the tolerance of experimental animals to hypoxia. Administration of insulin at the period of normalization of physiological functions after hypoxia produced a positive influence on the animal revival. Data are presented on the mechanism of insulin action in hypoxia.
在这项临床实验工作中，展示了有关成熟胎儿和窒息新生儿血浆胰岛素活性的数据；还记录了胰岛素对新生儿和性成熟大鼠在实验条件下缺氧过程及其后遗症消除的影响。结果证明，正常妊娠母亲所生新生儿的血浆胰岛素活性会增加。在母亲患有妊娠后半期毒血症的新生儿中，胰岛素活性出现了具有统计学意义的降低。胎儿和新生儿的死亡伴随着血浆胰岛素活性的显著降低。预先注射胰岛素可提高实验动物对缺氧的耐受性。在缺氧后生理功能恢复正常期间注射胰岛素，对动物苏醒产生了积极影响。文中还介绍了胰岛素在缺氧状态下的作用机制。
