在泰国东北部人群中，未发现血清素2A受体基因（rs6311）的-1438A/G多态性与重度抑郁症易感性之间存在关联。

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population.

作者信息

Tencomnao T, Thongrakard V, Phuchana W, Sritharathikhun T, Suttirat S

机构信息

Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

出版信息

Genet Mol Res. 2010 Jun 22;9(2):1171-6. doi: 10.4238/vol9-2gmr823.

DOI:10.4238/vol9-2gmr823

PMID:20589614

Abstract

Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP. We found no significant differences between the two groups with regard to both genotype distributions (chi(2) = 1.32, d.f. = 2, P = 0.516) and allele frequencies (chi(2) = 0.01, d.f. = 1, P = 0.913, odds ratio = 0.96, 95% confidence interval = 0.67-1.39). Therefore, this single nucleotide polymorphism appears not to be involved in the etiology of MDD.

摘要

多项证据表明，5-羟色胺受体2A（5-HTR2A）基因启动子中的-1438A/G单核苷酸多态性（rs6311）在调节该基因表达方面具有分子作用，这使得rs6311多态性成为关联研究的一个有前景的候选对象。我们在泰国东北部人群中寻找rs6311多态性与重度抑郁症（MDD）之间可能存在的关联。我们的研究纳入了180例MDD患者和183名无亲缘关系的健康对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）进行基因分型。我们发现，两组在基因型分布（卡方=1.32，自由度=2，P=0.516）和等位基因频率（卡方=0.01，自由度=1，P=0.913，优势比=0.96，95%置信区间=0.67-1.39）方面均无显著差异。因此，这种单核苷酸多态性似乎不参与MDD的病因学过程。