Ronpirin C, Tencomnao T, Wongpiyabovorn J
Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Genet Mol Res. 2010 Feb 2;9(1):208-14. doi: 10.4238/vol9-1gmr718.
Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls were included in our study. Genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism techniques. We found no overall differences in genotype distributions and allele frequencies when comparing between the two groups. When we analyzed a subset of psoriatic patients classified by onset and severity, only the -1438A allele was significantly increased in patients with late-onset psoriasis when compared with the healthy control group (chi(2) = 4.77, d.f. = 1, P = 0.029, odds ratio = 2.298 [95% confidence interval = 1.126-4.691]). This single nucleotide polymorphism may be involved in late-onset psoriasis in this Thai population.
血清素2A受体（5-HTR2A）的表达在银屑病（一种慢性炎症性皮肤病）中会增加。我们研究了5-HTR2A基因启动子区域的-1438A/G单核苷酸多态性（rs6311）与泰国人群银屑病之间可能存在的关联。我们的研究纳入了112例银屑病患者和151名无亲缘关系的健康对照。采用聚合酶链反应和限制性片段长度多态性技术进行基因分型。比较两组时，我们发现基因型分布和等位基因频率没有总体差异。当我们分析按发病和严重程度分类的银屑病患者亚组时，与健康对照组相比，仅晚发型银屑病患者的-1438A等位基因显著增加（χ² = 4.77，自由度 = 1，P = 0.029，优势比 = 2.298 [95%置信区间 = 1.126 - 4.691]）。这种单核苷酸多态性可能与该泰国人群的晚发型银屑病有关。
