Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Dig Endosc. 2010 Jul;22 Suppl 1:S57-62. doi: 10.1111/j.1443-1661.2010.00967.x.
Flat and depressed (nonpolypoid) colorectal lesions have been described for over two decades by Japanese investigators. These neoplastic lesions are typically smaller than polypoid ones and can be more difficult to identify during screening colonoscopy. In particular, depressed type colorectal lesions are usually small in size, with a number of studies showing them to be at greater risk for developing high-grade dysplasia or submucosal invasive cancer. It has also been suggested that they may follow a different carcinogenic pathway to flat elevated or protruding adenomas. This paper summarizes recent data of nonpolypoid colorectal neoplasms from Western and Asian countries.
日本研究人员二十多年前就已经描述了扁平且凹陷（非息肉样）的结直肠病变。这些肿瘤性病变通常比息肉样病变小，在筛查结肠镜检查中更难识别。特别是，凹陷型结直肠病变通常体积较小，多项研究表明其发生高级别异型增生或黏膜下浸润性癌的风险更高。也有人认为，它们可能遵循与扁平隆起或外凸性腺瘤不同的致癌途径。本文总结了来自西方国家和亚洲国家的非息肉样结直肠肿瘤的最新数据。
