类风湿关节炎患者的血清硒浓度
Serum selenium concentrations in rheumatoid arthritis.
作者信息
O'Dell J R, Lemley-Gillespie S, Palmer W R, Weaver A L, Moore G F, Klassen L W
机构信息
University of Nebraska Medical Center, Omaha 68198-2265.
出版信息
Ann Rheum Dis. 1991 Jun;50(6):376-8. doi: 10.1136/ard.50.6.376.
Abstract
Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.
摘要
硒是一种微量元素，是谷胱甘肽过氧化物酶的重要组成部分，该酶可保护细胞免受氧化损伤。已表明硒具有抗增殖、抗炎、抗病毒和免疫调节作用。研究发现，101例血清阳性类风湿性关节炎患者的血清硒浓度显著低于29例正常健康对照者（均值（标准差）分别为148（42）微克/升和160（25）微克/升），也低于8例纤维炎患者（148（42）微克/升和166（25）微克/升）。据推测，血清硒浓度可能会调节具有适当遗传背景的受试者中病毒或其他感染的影响，从而促进类风湿性关节炎的发展或进展。
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