Department of Nutritional Sciences at the University of Arizona, Tucson, Arizona 85721, USA.
Nutr Rev. 2010 Jul;68(7):418-28. doi: 10.1111/j.1753-4887.2010.00301.x.
Quercetin is a unique dietary polyphenol because it can exert biphasic dose-responses on cells depending on its concentration. Cancer preventative effects of quercetin are observed at concentrations of approximately 1-40 microM and are likely mediated by quercetin's antioxidant properties. Pro-oxidant effects are present at cellular concentrations of 40-100 microM. However, at higher concentrations, many novel pathways in addition to ROS contribute to its effects. The potent bioactivity of quercetin has led to vigorous study of this compound and revealed numerous pathways that could interact synergistically to prevent or treat cancer. The effect of intake and concentration on emerging pathways and how they may interact are discussed in this review.
槲皮素是一种独特的膳食多酚，因为它可以根据其浓度对细胞产生双相剂量反应。槲皮素的抗癌作用在约 1-40 μM 的浓度下观察到，这可能是由槲皮素的抗氧化特性介导的。在细胞浓度为 40-100 μM 时，会出现促氧化剂作用。然而，在更高的浓度下，除了 ROS 之外，许多新的途径也有助于其作用。槲皮素的强大生物活性导致了对这种化合物的大量研究，并揭示了许多可能协同作用以预防或治疗癌症的途径。本文综述了摄入和浓度对新兴途径的影响，以及它们可能如何相互作用。
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