Sheppard H, Burghardt C R, Long J P
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):213-24.
A number of DATS have been studied for agonist activity with dopamine (DA) and beta (beta) type adenylate cyclases and the most potent ones were found among the 6,7-DATs and the 5,6-DATs, respectively. None of the compounds tested possessed antagonist activity. The observed activities were not expected on the basis of structural analysis of model compounds such as apomorphine and 6,7-dihydroxy-1-benzyltetrahydroisoquinoline. A new view was constructed which suggests that the nitrogens of the DAT compounds were positioned better than those of the model compounds with regard to their binding sites.
已经对多种二烯丙基三硫（DATS）进行了与多巴胺（DA）和β型腺苷酸环化酶的激动剂活性研究，发现最有效的分别存在于6,7 - DATS和5,6 - DATS中。所测试的化合物均不具有拮抗剂活性。基于阿扑吗啡和6,7 - 二羟基 - 1 - 苄基四氢异喹啉等模型化合物的结构分析，无法预期观察到的活性。构建了一种新观点，表明二烯丙基三硫化合物的氮原子相对于其结合位点的定位比模型化合物的氮原子更好。
