Doaré L, Puech A J, Simon P
J Pharmacol. 1986 Jan-Mar;17(1):60-4.
2-N,N-dipropylamino 5,6-dihydroxytetralin (nPr2 ADTN), a potent dopaminergic agonist, induces the same polyphasic effects observed with apomorphine by Protais et al., (1983). The dose related sequence of behaviours in mice can be summed up as followed: to 0.9 to 3.9 micrograms.kg-1, a decrease in motor activity without any other effects; to 7.8 to 15.6 micrograms.kg-1, a return to control level or an increase in motility alone according to experimental conditions; to 31 to 62.5 micrograms.kg-1, a second phase of hypomotility when hypothermia develops; above 125 micrograms.kg-1, a second phase of hypermotility when both stereotypies and climbing behaviour appear. Hypothermia moreover, disappears. The effects of the nPr2 ADTN were compared with those of apomorphine obtained in others studies (Puech et al., 1974; Protais et al., 1983). The tetralin derivative differs from apomorphine in that the first phase of hypermotility it induces is greater, and that hypothermia disappears at high doses.
2-N，N-二丙基氨基5，6-二羟基四氢萘（nPr2 ADTN）是一种强效多巴胺能激动剂，可诱发与普罗泰等人（1983年）观察到的阿扑吗啡相同的多相效应。小鼠行为的剂量相关序列可总结如下：剂量为0.9至3.9微克·千克-1时，运动活性降低，无其他影响；剂量为7.8至15.6微克·千克-1时，根据实验条件，运动活性恢复至对照水平或仅运动活性增加；剂量为31至62.5微克·千克-1时，体温过低时出现第二阶段运动减少；剂量高于125微克·千克-1时，刻板行为和攀爬行为出现时出现第二阶段运动亢进。此外，体温过低消失。将nPr2 ADTN的效应与其他研究（皮克等人，1974年；普罗泰等人，1983年）中获得的阿扑吗啡的效应进行了比较。四氢萘衍生物与阿扑吗啡的不同之处在于，它诱导的第一阶段运动亢进更大，且高剂量时体温过低消失。
