Department of Radiation Physics, Kidwai Memorial Institute of Oncology, Bangalore, India.
J Appl Clin Med Phys. 2010 Apr 19;11(2):3076. doi: 10.1120/jacmp.v11i2.3076.
Intensity-modulated radiotherapy treatment demands stringent quality assurance and accurate dose determination for delivery of highly conformal dose to the patients. Generally 3D dose distributions obtained from a treatment planning system have to be verified by dosimetric methods. Mainly, a comparison of two-dimensional calculated and measured data in several coplanar planes is performed. In principle, there are many possibilities to measure two-dimensional dose distributions such as films, flat-panel electronic portal imaging devices (EPID), ion chambers and ionization chamber arrays, and radiographic and radiochromic films. The flat-panel EPIDs show a good resolution and offer a possibility for real-time measurements: however to convert the signal into dose, a separate commercial algorithm is required. The 2D ion chamber array system offers the real-time measurements. In this study, dosimetric characteristics of 2D ion chamber array matrix were analyzed for verification of radiotherapy treatments. The dose linearity and dose rate effect of the I'matriXX device was studied using 6 MV, 18 MV photons and 12 MeV electrons. The output factor was estimated using I'matriXX device and compared with ion chamber measurements. The ion chamber array system was found to be linear in the dose range of 2-500 cGy and the response of the detector was found to be independent of dose rate between 100 MU/min to 600 MU/min. The estimated relative output factor with I'matriXX was found to match very well with the ion chamber measurements. To check the final dose delivered during IMRT planning, dose distribution patterns such as field-in-field, pyramidal, and chair tests were generated with the treatment planning system (TPS) and the same was executed in the accelerator and measured with the I'matriXX device. The dose distribution pattern measured by the matrix device for field-in-field, pyramidal, and chair test were found to be in good agreement with the calculated dose distribution by TPS both for 6 and 18 MV photons (gamma < or = 1: 96%, criteria 3%, 3 mm). Two 7-field IMRT plans (one prostate, one head and neck) dose distribution patterns were also measured with I'matriXX device and compared with film dosimetry. The measurements and evaluation proves that I'matriXX can be used for quantifying absolute dose. Moreover, using I'matriXX as absolute dosimeter in IMRT field verification, avoids the time-consuming procedure of making ionometric measurement for absolute dose estimation and film for dose distribution verification. The I'matriXX can also used for routine quality assurance checks like flatness, symmetry, field width, and penumbra of the linear accelerator beam.
调强放射治疗需要严格的质量保证和精确的剂量测定,以将高适形剂量输送给患者。通常,治疗计划系统获得的三维剂量分布必须通过剂量测定方法进行验证。主要是在几个共面平面上进行二维计算数据和测量数据的比较。原则上,有许多可能性可以测量二维剂量分布,例如胶片、平板电子射野影像装置(EPID)、电离室和电离室阵列以及射线照相和辐射照相胶片。平板 EPID 具有良好的分辨率,并提供实时测量的可能性:但是,要将信号转换为剂量,需要单独的商业算法。二维电离室阵列系统提供实时测量。在这项研究中,分析了二维电离室阵列矩阵的剂量学特性,以验证放射治疗。使用 6 MV、18 MV 光子和 12 MeV 电子研究了 ImatriXX 设备的剂量线性和剂量率效应。使用 ImatriXX 设备估算了输出因子,并与电离室测量进行了比较。发现离子室阵列系统在 2-500 cGy 的剂量范围内呈线性,并且在 100 MU/min 至 600 MU/min 之间,探测器的响应与剂量率无关。发现用 ImatriXX 估算的相对输出因子与电离室测量非常吻合。为了检查调强放疗计划中最终输送的剂量,使用治疗计划系统(TPS)生成了场中场、金字塔和椅子测试等剂量分布模式,并在加速器中执行并使用 ImatriXX 设备进行测量。对于 6 和 18 MV 光子(γ<或=1:96%,标准 3%,3mm),矩阵设备测量的场中场、金字塔和椅子测试的剂量分布模式与 TPS 计算的剂量分布非常吻合。还用 ImatriXX 设备测量了两个 7 野调强放疗计划(一个前列腺,一个头颈部)的剂量分布模式,并与胶片剂量学进行了比较。测量和评估证明,ImatriXX 可用于量化绝对剂量。此外,在调强放疗场验证中使用 ImatriXX 作为绝对剂量计,可以避免费时的离子计测量绝对剂量估计和胶片剂量分布验证的过程。ImatriXX 还可用于线性加速器束的平坦度、对称性、射野宽度和半影等常规质量保证检查。