Shaw R, Cameron J A
Res Commun Chem Pathol Pharmacol. 1978 Feb;19(2):225-32.
The effect of endotoxin (LPS) on uterine cAMP was determined by measuring the levels of cAMP and cAMP phosphodiesterase after challenge. Two LPS preparations, isolated from wild type (WT) and Re chemotype mutant cells of Salmonella typhimurium were used. The pattern of termination differed with WT LPS resulting in expulsion of the fetuses, and Re LPS primarily causing the resorption of the fetuses. The animals challenged with WT LPS showed a decrease in uterine cAMP when the mice were starting to expel the fetuses while the Re LPS treated group maintained control levels of cAMP. Cyclic AMP phosphodiesterase also decreased in WT LPS and not the Re LPS group. These results suggest the possibility that uterine cAMP is involved in the expulsion of the fetuses.
通过在刺激后测量环磷酸腺苷（cAMP）和cAMP磷酸二酯酶的水平，确定内毒素（LPS）对子宫cAMP的影响。使用了从鼠伤寒沙门氏菌野生型（WT）和Re化学型突变细胞中分离出的两种LPS制剂。终止模式因WT LPS导致胎儿排出，而Re LPS主要导致胎儿吸收而有所不同。当小鼠开始排出胎儿时，用WT LPS攻击的动物子宫cAMP水平降低，而用Re LPS处理的组维持cAMP的对照水平。WT LPS组的cAMP磷酸二酯酶也降低，而Re LPS组则没有。这些结果表明子宫cAMP参与胎儿排出的可能性。
