Mitznegg P, Schubert E, Carl H
Arzneimittelforschung. 1976;26(9):1684-5.
The tension developed by muscle strips obtained from pregnant and non-pregnant rat uteri and uterine cyclic 3',5'-AMP was measured in the presence of increasing amounts of theophylline. In the pregnant uterus the initial tension was elevated by 112% and the tissue level of cAMP by 59% as compared to the normal organ. 1 mM theophylline relaxed the normal uterus by 81% and the pregnant uterus by 36% without any change in the cAMP concentrations. Higher amounts of theophylline (3-10 mM) able to relax the pregnant uterus completely also increased uterine cAMP in a dose dependent manner. It seems likely that the effect of high amounts of theophylline is mediated by cAMP, which, however, is not involved in the action of low (therapeutic) doses of the drug.
在存在递增剂量茶碱的情况下，对取自怀孕和未怀孕大鼠子宫的肌条以及子宫环磷酸腺苷（cAMP）产生的张力进行了测量。与正常子宫相比，怀孕子宫的初始张力升高了112%，cAMP的组织水平升高了59%。1 mM茶碱使正常子宫松弛了81%，使怀孕子宫松弛了36%，而cAMP浓度没有任何变化。能够使怀孕子宫完全松弛的更高剂量的茶碱（3 - 10 mM）也以剂量依赖的方式增加了子宫cAMP。似乎高剂量茶碱的作用是由cAMP介导的，然而，低（治疗）剂量的该药物作用并不涉及cAMP。
