使用射频消融术有效治疗慢性放射性直肠炎。
Effective treatment of chronic radiation proctitis using radiofrequency ablation.
作者信息
Zhou Chao, Adler Desmond C, Becker Laren, Chen Yu, Tsai Tsung-Han, Figueiredo Marisa, Schmitt Joseph M, Fujimoto James G, Mashimo Hiroshi
机构信息
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics Massachusetts Institute of Technology, Cambridge, MA, USA.
出版信息
Therap Adv Gastroenterol. 2009 Jan 1;2(3):149-156. doi: 10.1177/1756283x08103341.
Endoscopic argon plasma coagulation and bipolar electrocautery are currently preferred treatments for chronic radiation proctitis, but ulcerations and strictures frequently occur. Radiofrequency ablation (RFA) has been successful for mucosal ablation in the esophagus. Here we report the efficacy of RFA with the BarRx Halo(90) system in three patients with bleeding from chronic radiation proctitis. In all cases, the procedure was well tolerated and hemostasis was achieved after 1 or 2 RFA sessions. Re-epithelialization of squamous mucosa was observed over areas of prior hemorrhage. No stricturing or ulceration was seen on follow-up up to 19 months after RFA treatment. Real-time endoscopic optical coherence tomography (EOCT) visualized epithelialization and subsurface tissue microvasculature pre- and post-treatment, demonstrating its potential for follow-up assessment of endoscopic therapies.
内镜下氩等离子体凝固术和双极电凝术是目前治疗慢性放射性直肠炎的首选方法，但溃疡和狭窄仍频繁发生。射频消融术（RFA）已成功应用于食管黏膜消融。在此，我们报告使用BarRx Halo(90)系统对3例慢性放射性直肠炎出血患者进行射频消融术的疗效。在所有病例中，该操作耐受性良好，经过1或2次射频消融术后实现了止血。在先前出血区域观察到鳞状黏膜重新上皮化。射频消融治疗后长达19个月的随访中未发现狭窄或溃疡。实时内镜光学相干断层扫描（EOCT）可在治疗前后可视化上皮化和黏膜下组织微血管，证明其在内镜治疗随访评估中的潜力。
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